Anti-CNTF Polyclonal Antibody

CAT: 0793-39-2157-100Size: 100 µg/VialDry Ice: NoHazardous: No

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CAT#:0793-39-2157-100Size:100 µg/Vial

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Ciliary neurotrophic factor (CNTF) is a potent polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes survival, neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The CNTF gene is located on chromosome 11, as determined using human-hamster somatic cell hybrids. The CNTF protein is highly conserved in evolution. The amino acid (aa) sequences of rat and rabbit CNTF translated from cDNAs display approx. 85% homology with the deduced aa sequence encoding human CNTF. CNTF induces weight loss and improves glucose tolerance in humans and rodents. CNTF is thought to act centrally by inducing hypothalamic neurogenesis to modulate food intake and peripherally by altering hepatic gene expression, in a manner similar to that of leptin.

Product Name Alternative

Ciliary neurotrophic factor; CNTF; CNTF

Gene Name

CNTF

Gene ID

1270

UniProt

P26441

Host

Rabbit

Reactivity

Human

Immunogen

E.coli-derived Human CNTF recombinant protein (Position: A2-M200) . Human CNTF shares 83% and 84% amino acid (aa) sequence identity with Mouse and Rat CNTF, respectively.

Target Antigen

Ciliary neurotrophic factor

Clonality

Polyclonal

Applications

WB, IHC-P

Purification

Immunogen affinity purified.

Components

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3. Reconstitute : Add 0.2ml of distilled water will yield a concentration of 500ug/mL.

Storage Conditions

At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

Applications Notes

Western blot : 0.1-0.5μg/ml; Immunohistochemistry (Paraffin-embedded Section) : 0.5-1μg/ml

Isotype

Rabbit IgG

UniProtKB · P26441

Ciliary neurotrophic factor

CNTF_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P26441
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: CNTF
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: CNTF
EC number: —
Processing: —
Secondary accessions: B2RAB2

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Cellular component

CytoplasmSecreted

Molecular function

Developmental proteinGrowth factor

Biological process

DifferentiationNeurogenesis

Related Products

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32-1111-20	CNTF His Recombinant Protein
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32-7083-50	Recombinant Human Ciliary Neurotrophic Factor/CNTF
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Alternative Products

Catalog	Name
TMAB-04499-01	Anti-CNTF Polyclonal Antibody
TA319020	Rabbit polyclonal anti-CNTF antibody
MBS8105880-01	Anti-CNTF Antibody, Rabbit Polyclonal
MBS8519724-01	CNTF Polyclonal Antibody
APR11614G	Polyclonal CNTF Antibody
MBS176996-01	Anti-CNTF Antibody
Y058079	Anti-CNTF