Anti-MBD2 Polyclonal Antibody

CAT: 0793-39-2005-100Size: 100 µg/VialDry Ice: NoHazardous: No

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CAT#:0793-39-2005-100Size:100 µg/Vial

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Methyl-CpG-binding domain protein 2 is a protein that in humans is encoded by the MBD2 gene. It is mapped to 18q21.2. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG-binding domain (MBD) . Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing.

Product Name Alternative

Methyl-CpG-binding domain protein 2; Demethylase; DMTase; Methyl-CpG-binding protein MBD2; MBD2

Gene Name

MBD2

Gene ID

8932

UniProt

Q9UBB5

Host

Rabbit

Reactivity

Human

Immunogen

E.coli-derived human MBD2 recombinant protein (Position: W159-A411) . Human MBD2 shares 98% amino acid (aa) sequence identity with mouse MBD2.

Target Antigen

Methyl-CpG-binding domain protein 2

Clonality

Polyclonal

Applications

Purification

Immunogen affinity purified.

Format

Lyophilized

Components

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3. Reconstitute : Add 0.2ml of distilled water will yield a concentration of 500ug/mL.

Storage Conditions

At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

Applications Notes

Western blot : 0.1-0.5μg/ml

Isotype

Rabbit IgG

UniProtKB · Q9UBB5

Methyl-CpG-binding domain protein 2

MBD2_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q9UBB5
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: MBD2
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: O95242, Q9UIS8

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

ChromosomeNucleus

Molecular function

DNA-binding

PTM

Phosphoprotein

Biological process

TranscriptionTranscription regulation

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