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Anti-Human CD243 APC (Clone : UIC2)

CAT: 0793-30-2614-100Size: 100 TestsDry Ice: NoHazardous: No
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CAT#:0793-30-2614-100Size:100 Tests
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Description
CD243, also known as multidrug resistant protein 1 (MDR-1) or P-glycoprotein (Pgp) is an ATP binding cassette (ABC) -containing efflux transporter for xenobiotic lipophilic compounds with broad substrate Specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. It is expressed in many tissues, including the brain, liver, pancreas, testes, kidney, and blood (B, T, NK cells, but not monocytes) .Specificity : The mouse monoclonal antibody UIC2 recognizes an extracellular epitope on CD243 (MDR-1), an approximately 170 kDa ABC transporter expressed on hematopoietic stem cells, B, T, and NK cells, or on many multidrug resistant cancer cells. This antibody preferentially recognizes CD243 in the process of transporting substrate.
Product Name Alternative
P-Glycoprotein, CLCS, MDR1, PGY1, ABC20, GP170, ABCB1, ABC transporter, ATP binding cassette subfamily B member 1
Gene Name
ABCB1
Gene ID
5243
Reactivity
Human
Immunogen
NIH 3T3 cells transfected with human CD243 (MDR-1) cDNA
Target Antigen
CD243
Clonality
Monoclonal
Clone
UIC2
Applications
FACS
Purification
The purified antibody is conjugated with allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
Components
Formulation : Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide
Storage Conditions
Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Applications Notes
Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
Isotype
Mouse IgG2a kappa
Conjugate
APC

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Alternative Products

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