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Polyclonal antibody to TRAF-4

CAT: 0793-20-1100-50Size: 50 μLDry Ice: NoHazardous: No
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CAT#:0793-20-1100-50Size:50 μL
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Description
This antibody recognizes TRAF4. Human TRAF4 is a 470 amino acid protein. The TRAF (TNF receptor-associated factor) family is a group of adapter proteins (TRAFs 1-6) that link a wide variety of cell surface receptors to diverse signaling cascades leading to the activation of NF-kB and mitogen-activated protein kinases. TRAFs are major signal transducers for both the TNF and IL- 1/TLR receptor superfamilies and collectively play important functions in both adaptive and innate immunity. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. TRAFs interact with a variety of proteins that regulate receptor-induced cell death or survival, and TRAF-mediated signaling can promote cell survival or interfere with death receptor-induced apoptosis.
Product Name Alternative
TRAF4||CART1||MLN62||RNF83
Gene Name
TRAF4
Gene ID
9618
UniProt
Q9BUZ4
Host
Rabbit
Reactivity
Rat, Mouse, Human
Immunogen
A synthetic peptide human TRAF-4 (amino acids 1-17 MPGFDYKFLEKPKRRLL) was used as immunogen for this antibody
Target Antigen
TRAF-4
Clonality
Polyclonal
Applications
IP, IHC, WB
Format
Sera
Components
50 μl sera
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
WB: 1:1000-1:2000, IHC (paraffin) : 1:1000-1:5000, IHC (frozen) : Users should optimize, IP: 1:50-1:200
Isotype
Rabbit IgG

UniProtKB · Q9BUZ4

TNF receptor-associated factor 4

TRAF4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9BUZ4
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TRAF4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.3.2.27
Processing
—
Secondary accessions
O75615, Q14848, Q2KJU4, Q2PJN8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisImmunityInnate immunityUbl conjugation pathway

Cellular component

Cell junctionCell membraneCytoplasmCytoskeletonMembraneNucleusTight junction

Domain

Coiled coilRepeatZinc-finger

Molecular function

Developmental proteinTransferase

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Ligand

Metal-bindingZinc

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