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Polyclonal antibody to Mouse TRAF-2

CAT: 0793-20-1097-50Size: 50 μLDry Ice: NoHazardous: No
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CAT#:0793-20-1097-50Size:50 μL
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Description
This antibody recognizes TRAF2, which is a member of TRAF (TNF receptor-associated factor) adapter proteins composed 501 amino acids. It Links TNFRs (TNF Receptors) to the SAPKs (Stress-Activated Protein Kinases) and p38s. TRAF2 can activate ASK1 (Apoptosis Signal-Regulating Kinase-1) in vivo and can interact in vivo with the amino- and carboxyl-terminal noncatalytic domains of the ASK1 polypeptide. Expression of the amino-terminal noncatalytic domain of ASK1 can inhibit TNF and TRAF2 activation of SAPK. TRAF2 is a potential mediator of CD40 signaling. In vitro, TRAF2 and TRAF3 bind to the CD40 Cytoplasmic Tail (CD40CT) with much higher affinity than TRAF5 and TRAF6 (TNF Receptor Associated Factor-6) and that TRAF2 and TRAF3 bind to different residues of the CD40CT. The TRAF2-binding site of the CD40CT is critical for NF-KappaB and SAPK activation, as well as the UP-regulation of the ICAM1 (Intercellular Adhesion Molecule-1) .
Product Name Alternative
E3 ubiquitin-protein ligase TRAF2, RING-type E3 ubiquitin transferase TRAF2
Gene Name
Traf2
Gene ID
22030
UniProt
P39429
Host
Rabbit
Reactivity
Mouse
Immunogen
A synthetic peptide of mouse TRAF-2 (amino acids 250-271 CSFLEAQASPGTLNQVGPELLQR) was used as immunogen for this antibody
Target Antigen
MTRAF-2
Clonality
Polyclonal
Applications
IP, IHC, WB
Format
Sera
Components
50 μl sera
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
WB: 1:1000-1:2000, IHC (paraffin) : 1:1000-1:5000, IHC (frozen) : Users should optimize, IP: 1:50-1:200
Isotype
Rabbit IgG

UniProtKB · P39429

TNF receptor-associated factor 2

TRAF2_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
P39429
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Traf2
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
—
EC number
2.3.2.27
Processing
—
Secondary accessions
A2AJA3, O54896
Protein keywords

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisUbl conjugation pathway

Domain

Coiled coilRepeatZinc-finger

Cellular component

Cytoplasm

Technical term

Direct protein sequencingReference proteome

Ligand

Lipid-bindingMetal-bindingZinc

Molecular function

Transferase

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