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Polyclonal antibody to TRAF-2

CAT: 0793-20-1095-50Size: 50 μLDry Ice: NoHazardous: No
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CAT#:0793-20-1095-50Size:50 μL
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Description
This antibody recognizes TRAF2, which is a member of TRAF (TNF receptor-associated factor) adapter proteins composed 501 amino acids. It Links TNFRs (TNF Receptors) to the SAPKs (Stress-Activated Protein Kinases) and p38s. TRAF2 can activate ASK1 (Apoptosis Signal-Regulating Kinase-1) in vivo and can interact in vivo with the amino- and carboxyl-terminal noncatalytic domains of the ASK1 polypeptide. Expression of the amino-terminal noncatalytic domain of ASK1 can inhibit TNF and TRAF2 activation of SAPK. TRAF2 is a potential mediator of CD40 signaling. In vitro, TRAF2 and TRAF3 bind to the CD40 Cytoplasmic Tail (CD40CT) with much higher affinity than TRAF5 and TRAF6 (TNF Receptor Associated Factor-6) and that TRAF2 and TRAF3 bind to different residues of the CD40CT. The TRAF2-binding site of the CD40CT is critical for NF-KappaB and SAPK activation, as well as the UP-regulation of the ICAM1 (Intercellular Adhesion Molecule-1) .
Product Name Alternative
TRAF2||TRAP3
Gene Name
TRAF2
Gene ID
7186
UniProt
Q12933
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide of human TRAF-2 (amino acids 87-106 SSSAFPDNAARREVESLPAV) was used as immunogen for this antibody
Target Antigen
TRAF-2
Clonality
Polyclonal
Applications
WB, IHC, IP
Format
Sera
Components
50 μl sera
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
WB: 1:1000-1:2000, IHC (paraffin) : 1:1000-1:5000, IHC (frozen) : Users should optimize, IP: 1:50-1:200
Isotype
Rabbit IgG

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MBS668816-01Polyclonal Antibody to TRAF-2
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