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Polyclonal antibody to DEDD2 (DED4)

CAT: 0793-20-1061-50Size: 50 μLDry Ice: NoHazardous: No
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CAT#:0793-20-1061-50Size:50 μL
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Description
This antibody recognizes DEDD2/Flame-3; human DED2/Flame-3 is a 326 amino acid protein. This protein belongs to a family of single DED-containing proteins that is targeted to the nucleus. Several DED-containing proteins are involved in the regulation of apoptosis through their interactions with DED-containing caspases. It is thought that DEDD2 and its closely related homologue DEDD may mediate cell death by binding to the DED-containing caspases -8 and -10, and targeting them to the nucleus following death receptor induced apoptosis. However, the function of DEDD2 and DEDD remain to be fully elucidated, and they may also have roles in cellular processes other than apoptosis.
Product Name Alternative
DEDD2||FLAME3||PSEC0004
Gene Name
DEDD2
Gene ID
162989
UniProt
Q8WXF8
Host
Rabbit
Reactivity
Dog, Rat, Mouse, Human
Immunogen
A synthetic peptide of DEDD2 (DED4) protein (amino acids 210-228 GPALEQGVASRRPQALARQ) was used as immunogen for this antibody
Target Antigen
DEDD2 (DED4)
Clonality
Polyclonal
Applications
WB
Format
Sera
Components
50 μl sera
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
WB: 1:1000-1:5000
Isotype
Rabbit IgG

UniProtKB · Q8WXF8

DNA-binding death effector domain-containing protein 2

DEDD2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8WXF8
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DEDD2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q8NBR2, Q8NES1, Q8TAA8, Q96D35
Protein keywords

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisTranscriptionTranscription regulation

Molecular function

DNA-binding

Cellular component

Nucleus

Technical term

Proteomics identificationReference proteome

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