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Anti-DEDD2 (DED4) Antibody

CAT: 0519-A11263Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0519-A11263Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Boster Bio Anti-DEDD2 (DED4) Antibody (Catalog# A11263) . Tested in WB application (s) . This antibody reacts with Canine, Rat, Mouse, Human.
Synonyms
DNA-binding death effector domain-containing protein 2; DED-containing protein FLAME-3; FADD-like anti-apoptotic molecule 3; DEDD2; FLAME3; PSEC0004
Gene Name
DEDD2
UniProt
Q8WXF8
Host
Rabbit
Reactivity
Canine, Rat, Mouse, Human
Immunogen
A synthetic peptide of DEDD2 (DED4) protein (amino acids 210-228 GPALEQGVASRRPQALARQ)
Clonality
Polyclonal
Tissue Specificity
Expressed in most tissues. High levels were found in liver, kidney, heart, ovary, spleen, testes, skeletal muscle and peripheral blood leukocytes. Expression was absent or low in colon and small intestine. Expression is relatively high in the tumor cell lines chronic myologenous leukemia K-562 and the colorectal adenocarcinoma SW480. Expression is moderate in the cervical carcinoma HeLa, the Burkitt's lymphoma Raji, the lung carcinoma A-549, and the melanoma G-361. In contrast, two leukemia cell lines, HL-60 (promyelocytic leukemia) and MOLT-4 (lymphoblastic leukemia), show relatively low levels.
Applications
WB
Field of Research
Apoptosis, Cell Biology, Receptors
Concentration
0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Dilution
WB: 1:1000-1:5000
Form
Liquid
Function
May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3.
Molecular Weight
36179 MW
Shipping Conditions
Available
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Fragment
Rabbit IgG
Other Gene Names
DNA-binding death effector domain-containing protein 2
Subcellular Location
Nucleus, nucleolus. Nuclear, accumulated in subnuclear structures resembling nucleoli.
Protein Name
DNA-binding death effector domain-containing protein 2

UniProtKB · Q8WXF8

DNA-binding death effector domain-containing protein 2

DEDD2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8WXF8
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DEDD2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q8NBR2, Q8NES1, Q8TAA8, Q96D35
Protein keywords

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisTranscriptionTranscription regulation

Molecular function

DNA-binding

Cellular component

Nucleus

Technical term

Proteomics identificationReference proteome

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