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Polyclonal Antibody to RAX

CAT: 0793-11-13004-100Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0793-11-13004-100Size:100 µg
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Description
RAX or PRKRA (retina and anterior neural fold homeobox) is a homeobox-containing transcription factor. It plays an important role in eye development by regulating the initial specification of retinal cells. In the absence of double-stranded RNA, RAX activates EIF2AK2/PKR, so as to phosphorylate EIF2S1/EFI2-alpha leading to inhibition of translation and induction of apoptosis. RAX has been reported to be essential for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Mutations in this gene have been reported in patients with defects in ocular development, including microphthalmia, anophthalmia and coloboma. RAX is expressed in blood, bone, brain, spleen and adipose tissues.
Product Name Alternative
PRKRA||PACT||RAX||HSD-14||HSD14
Gene Name
PRKRA
Gene ID
8575
UniProt
O75569
Host
Rabbit
Reactivity
Human
Immunogen
A partial length recombinant RAX protein (amino acids 100-313) was used as the immunogen for this antibody.
Target Antigen
RAX
Clonality
Polyclonal
Applications
WB
Purification
Protein A Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Western blot analysis: 1-2μg/mL
Isotype
Rabbit IgG

UniProtKB · O75569

Interferon-inducible double-stranded RNA-dependent protein kinase activator A

PRKRA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O75569
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PRKRA
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A8K3I6, Q53G24, Q6X7T5, Q8NDK4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cytoplasm

Disease

Disease variantDystoniaParkinsonism

Biological process

Host-virus interactionRNA-mediated gene silencing

PTM

Phosphoprotein

Domain

Repeat

Molecular function

RNA-binding

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