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Polyclonal Antibody to Cbx5

CAT: 0793-11-12012-100Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0793-11-12012-100Size:100 µg
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Description
Chromobox homolog 5 (Cbx5), lso known as HP1 is an evolutionarily conserved non-histone chromosomal protein involved in many biological progresses, such as heterochromatin formation, transcriptional regulation, DNA recombination and damage repair, RNA interference, kinetochore protein assembly, chromatin condensation and sister chromatid cohesion regulation. It binds lysine 9-methylated histone H3 (H3K9me), a hallmark of heterochromatin, and plays a crucial role in forming higher-order chromatin structures.Cbx5 has a conserved N-terminal chromo domain (CD), 3 a non-conserved hinge region, and a C-terminal chromo shadow domain. It localizes to centromeres in interphase through its CD domain, whereas mitotic centromeric localization depends on the CSD domain (CSD) . Down regulation of Cbx5 has also been linked to the higher invasive potential of breast cancer cells.
Product Name Alternative
CBX5||HP1A
Gene Name
CBX5
Gene ID
23468
UniProt
P45973
Host
Rabbit
Reactivity
Human
Immunogen
Full length recombinant Cbx5 protein was used as the immunogen for this antibody.
Target Antigen
Cbx5
Clonality
Polyclonal
Applications
WB
Purification
Protein A Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Western blot analysis: 1-2 μg/mL
Isotype
Rabbit IgG

UniProtKB · P45973

Chromobox protein homolog 5

CBX5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P45973
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CBX5
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B2R8T9
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Cellular component

CentromereChromosomeNucleus

Biological process

Host-virus interaction

Domain

Repeat

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Alternative Products

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MBS8567434-01CBX5 Polyclonal Antibody
MBS669056-01Polyclonal Antibody to Cbx5

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