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Polyclonal Antibody to IFIT2

CAT: 0793-11-4059-25Size: 25 µgDry Ice: NoHazardous: No
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CAT#:0793-11-4059-25Size:25 µg
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Description
Interferon-induced protein with tetratricopeptide repeats 2 (IFIT2) is one of four related human (ISG56/IFIT1, ISG54/IFIT2, ISG60/IFIT3, ISG58/IFIT5) and three related mouse proteins (Ifit1, Ifit2, Ifit3) characterized by tetratricopeptide motifs. IFIT2 interacts with eukaryotic initiation factor 3 (eIF3) e and eIF3c to inhibit translation. IFIT2 interacts with some AU-rich RNA regions, which seems to be associated with antiviral activity. IFIT2 possesses antiviral activity against corona virus and West Nile virus by acting on the capped viral mRNA and protects from lethal vesicular stomatitis virus neuropathogenesis. Besides the antiviral activity, IFIT2 expression was associated with induction of apoptosis. IFIT2 may alter proinflammatory cytokine response and therefore be involved in the development of septic shock.
Product Name Alternative
IFIT2||CIG-42||G10P2||IFI54||ISG54
Gene Name
IFIT2
Gene ID
3433
UniProt
P09913
Host
Rabbit
Reactivity
Human
Immunogen
A partial length recombinant IFIT2 protein (amino acids 150-370) was used as the immunogen for this antibody.
Target Antigen
IFIT2
Clonality
Polyclonal
Applications
WB
Purification
Protein A Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Western blot analysis: 2-4μg/mL
Isotype
Rabbit IgG

UniProtKB · P09913

Interferon-induced protein with tetratricopeptide repeats 2

IFIT2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P09913
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IFIT2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
IFIT-2
EC number
—
Processing
—
Secondary accessions
Q5T767
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

Acetylation

Biological process

Antiviral defenseApoptosisImmunityInnate immunity

Cellular component

CytoplasmEndoplasmic reticulum

Domain

RepeatTPR repeat

Molecular function

RNA-binding

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Alternative Products

CatalogName
JOT-AP08681-01IFIT2 Polyclonal Antibody
NBP2-98193-50ulRabbit Polyclonal IFIT2 Antibody
C28339IFIT2 Polyclonal Conjugated Antibody
TA377339IFIT2 Rabbit Polyclonal Antibody

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