Docosanoic acid-d3

• Description:

  Docosanoic acid-d3 (Behenic acid-d3) is the deuterium labeled Docosanoic acid (HY-W013049) . Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a Kd of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans[1][2][3].

• Product Name Alternative:

  Behenic acid-d3

• UNSPSC:

  12352211

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  DNA/RNA Synthesis; Endogenous Metabolite; Isotope-Labeled Compounds

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Cancer; Metabolic Disease

• Purity:

  99.79

• Solubility:

  DMSO : 1 mg/mL (ultrasonic)

• Smiles:

  [2H]C([2H])([2H])CCCCCCCCCCCCCCCCCCCCC(O)=O

• Molecular Formula:

  C22H41D3O2

• Molecular Weight:

  343.60

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Cater NB, et al. Behenic acid is a cholesterol-raising saturated fatty acid in humans. Am J Clin Nutr. 2001 Jan;73 (1) :41-4.|[3]Moreira DK, et al. Evaluation of structured lipids with behenic acid in the prevention of obesity. Food Res Int. 2017 May;95:52-58. |[4]Iijima H, et al. The inhibitory action of long-chain fatty acids on the DNA binding activity of p53. Lipids. 2006 Jun;41 (6) :521-7.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  [1193721-67-3]