Docosanoic acid

• Description :

  Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a Kd of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans[1][2][3].

• Product Name Alternative :

  Behenic acid

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  DNA/RNA Synthesis; Endogenous Metabolite

• Type :

  Natural Products

• Related Pathways :

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cancer; Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/Docosanoic_acid.html

• Purity :

  99.40

• Solubility :

  DMF : 9.09 mg/mL (ultrasonic; warming; heat to 60°C) |DMSO : 1 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL

• Smiles :

  CCCCCCCCCCCCCCCCCCCCCC(O)=O

• Molecular Formula :

  C22H44O2

• Molecular Weight :

  340.59

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Cater NB, et al. Behenic acid is a cholesterol-raising saturated fatty acid in humans. Am J Clin Nutr. 2001 Jan;73 (1) :41-4.|[2]Moreira DK, et al. Evaluation of structured lipids with behenic acid in the prevention of obesity. Food Res Int. 2017 May;95:52-58. |[3]Iijima H, et al. The inhibitory action of long-chain fatty acids on the DNA binding activity of p53. Lipids. 2006 Jun;41 (6) :521-7.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  Human Endogenous Metabolite

• CAS Number :

  [112-85-6]