β-catenin-IN-6

β-catenin-IN-6

• CAS Number: 1039731-99-1
• UNSPSC Description: β-catenin-IN-6 is a β-catenin inhibitor, targeting to canonical Wingless-related integration site signaling pathway. β-catenin-IN-6 inhibits human colorectal cancer cells proliferation, as well as in a β-catenin/RK3E mouse model[1][2].
• Target Antigen: β-catenin
• Type: Reference compound
• Related Pathways: Stem Cell/Wnt
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/β-catenin-in-6.html
• Purity: 98.65
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(C1=CN=C(C=C1)Cl)NC2=CC=C(CNC3=C4C=CC=CC4=NC(NC)=N3)C=C2
• Molecular Weight: 418.88
• References & Citations: [1]Dehnhardt CM, et al. Design and synthesis of novel diaminoquinazolines with in vivo efficacy for beta-catenin/T-cell transcriptional factor 4 pathway inhibition. J Med Chem. 2010 Jan 28;53(2):897-910. |[2]McCoy MA, et al. Biophysical Survey of Small-Molecule β-Catenin Inhibitors: A Cautionary Tale. J Med Chem. 2022 May 26;65(10):7246-7261.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported