Guanosine 5'-diphosphate (ditromethamine)

Guanosine 5'-diphosphate (ditromethamine)

• CAS Number: 103192-39-8
• UNSPSC Description: Guanosine 5'-diphosphate ditromethamine is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K+ channel. Guanosine 5'-diphosphate ditromethamine is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate ditromethamine can be used in the research of inflammation, such as anemia of inflammation (AI)[1][2].
• Target Antigen: Endogenous Metabolite; Potassium Channel
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/guanosine-5-diphosphate-ditromethamine.html
• Smiles: O=P(O)(OP(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=NC3=C2N=C(N)NC3=O)O1)(O)=O)O.OCC(CO)(N)CO.OCC(CO)(N)CO
• Molecular Weight: 685.47
• References & Citations: [1]S Kajioka, et al. Guanosine diphosphate activates an adenosine 5'-triphosphate-sensitive K+ channel in the rabbit portal vein. J Physiol. 1991 Dec;444:397-418. |[2]Angmo S, et al. Identification of Guanosine 5'-diphosphate as Potential Iron Mobilizer: Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway. Sci Rep. 2017 Jan 5;7:40097.
• Shipping Conditions: Room temperature
• Clinical Information: Phase 3