Guanosine 5'-diphosphate (disodium salt)

Guanosine 5'-diphosphate (disodium salt)

• CAS Number: 7415-69-2
• UNSPSC Description: Guanosine 5'-diphosphate (GDP) disodium salt, a purine nucleoside diphosphate, is interconverted to guanosine by the action of exonucleotidase and phosphorylation of nucleoside to guanine. Guanosine 5'-diphosphate disodium salt activates adenosine 5'-triphosphate-sensitive K+ channel and is used to study the kinetics and characteristics of GTPases such as those associated with G-protein coupled receptors (GPCR). Guanosine 5'-diphosphate disodium salt is a potential iron mobilizer, which prevents the Hepcidin (HY-P70400)-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Elevated levels of guanosine 5’-diphosphate are associated with the pathogenesis of neurological diseases. Guanosine 5'-diphosphate disodium salt is promising for the research of inflammation, such as anemia of inflammation (AI)[1][2][3][4][5].
• Target Antigen: Endogenous Metabolite; Potassium Channel
• Type: Oligonucleotides
• Related Pathways: Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology; Neurological Disease; Cancer
• Assay Protocol: https://www.medchemexpress.com/guanosine-5-diphosphate-disodium-salt.html
• Purity: 99.0
• Solubility: H2O : 62.5 mg/mL (ultrasonic)
• Smiles: O[C@H]1[C@@H](O)[C@H](N2C(N=C(N)NC3=O)=C3N=C2)O[C@@H]1COP(OP(O)([O-])=O)([O-])=O.[2Na+]
• Molecular Weight: 487.16
• References & Citations: [1]Angmo S, et al. Identification of Guanosine 5'-diphosphate as Potential Iron Mobilizer: Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway. Sci Rep. 2017 Jan 5;7:40097.|[2]S Kajioka, et al. Guanosine diphosphate activates an adenosine 5'-triphosphate-sensitive K+ channel in the rabbit portal vein. J Physiol. 1991 Dec;444:397-418. |[3]Ciruela F. Guanosine behind the scene. J Neurochem. 2013 Aug;126(4):425-7.|[4]Raj GV, et al. Guanosine phosphate binding protein coupled receptors in prostate cancer: a review. J Urol. 2002 Mar;167(3):1458-63.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, sealed storage, away from moisture)
• Clinical Information: Phase 3