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Niclosamide (Standard)

CAT: 0804-HY-B0497R-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0497R-01Size:10 mg
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Description
Niclosamide (Standard) is the analytical standard of Niclosamide. This product is intended for research and analytical applications. Niclosamide (BAY2353) is an orally active antihelminthic agent used in parasitic infection research[1]. Niclosamide is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells[4]. Niclosamide has biological activities against cancer, inhibits DNA replication in Vero E6 cells[2][3][5].
CAS Number
50-65-7
Product Name Alternative
BAY2353 (Standard)
UNSPSC
12352005
Hazard Statement
H400, H410
Target
Antibiotic; Parasite; Reference Standards; STAT
Type
Reference Standards
Related Pathways
Anti-infection; JAK/STAT Signaling; Others; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/niclosamide-standard.html
Purity
99.16
Smiles
O=C(NC1=CC=C([N+]([O-])=O)C=C1Cl)C2=CC(Cl)=CC=C2O
Molecular Formula
C13H8Cl2N2O4
Molecular Weight
327.12
Precautions
H400, H410
References & Citations
[1]P Andrews, et al. The biology and toxicology of molluscicides, Bayluscide. Pharmacol Ther. 1982;19 (2) :245-95.|[2]Wei Chen, et al. Niclosamide: Beyond an antihelminthic drug. Cell Signal. 2018 Jan;41:89-96.|[3]Kei Satoh, et al. Identification of Niclosamide as a Novel Anticancer Agent for Adrenocortical Carcinoma. Clin Cancer Res. 2016 Jul 15;22 (14) :3458-66.|[4]Xiaomei Ren, et al. Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway. ACS Med Chem Lett. 2010 Sep 7;1 (9) :454-9.|[5]Chang-Jer Wu, et al. Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide. Antimicrob Agents Chemother. 2004 Jul;48 (7) :2693-6.
Shipping Conditions
Room Temperature
Storage Conditions
4°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards
Clinical Information
Launched

Chemical Information

Niclosamide

Niclosamide is a secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections. It has a role as an anticoronaviral agent, a piscicide, a molluscicide, an antiparasitic agent, an anthelminthic drug, an apoptosis inducer and a STAT3 inhibitor. It is a secondary carboxamide, a member of benzamides, a C-nitro compound, a member of salicylanilides and a member of monochlorobenzenes. It is functionally related to a 5-chlorosalicylic acid.

CAS Number50-65-7
PubChem CID4477
IUPAC Name5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
Molecular FormulaC13H8Cl2N2O4
Molecular Weight327.12
XLogP4
Topological Polar Surface Area95.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count21
Formal Charge0
Complexity404
SMILES
C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O
InChI
InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
InChIKey
RJMUSRYZPJIFPJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Niclosamide
CAS: 50-65-7
CID: 4477
Formula: C13H8Cl2N2O4
MW: 327.12
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight327.12
XLogP34
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass325.9861121
Monoisotopic Mass325.9861121
Topological Polar Surface Area95.2 Ų
Heavy Atom Count21
Formal Charge0
Complexity404
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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