Niclosamide (monohydrate)

• Description :

  Niclosamide (BAY2353) monohydrate is an orally active antihelminthic agent used in parasitic infection research[1]. Niclosamide monohydrate is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells[4]. Niclosamide monohydrate has biological activities against cancer, and inhibits DNA replication in Vero E6 cells[2][3][5].

• Product Name Alternative :

  BAY2353 monohydrate

• UNSPSC :

  12352005

• Hazard Statement :

  H410

• Target :

  Antibiotic; Parasite; STAT

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; JAK/STAT Signaling; Stem Cell/Wnt

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Infection

• Assay Protocol :

  https://www.medchemexpress.com/Niclosamide-monohydrate.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(NC1=CC=C([N+]([O-])=O)C=C1Cl)C2=CC(Cl)=CC=C2O.O

• Molecular Formula :

  C13H10Cl2N2O5

• Molecular Weight :

  345.13

• Precautions :

  P273-P391-P501

• References & Citations :

  [1]P Andrews, et al. The biology and toxicology of molluscicides, Bayluscide. Pharmacol Ther. 1982;19 (2) :245-95.|[2]Wei Chen, et al. Niclosamide: Beyond an antihelminthic drug. Cell Signal. 2018 Jan;41:89-96.|[3]Kei Satoh, et al. Identification of Niclosamide as a Novel Anticancer Agent for Adrenocortical Carcinoma. Clin Cancer Res. 2016 Jul 15;22 (14) :3458-66.|[4]Xiaomei Ren, et al. Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway. ACS Med Chem Lett. 2010 Sep 7;1 (9) :454-9.|[5]Chang-Jer Wu, et al. Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide. Antimicrob Agents Chemother. 2004 Jul;48 (7) :2693-6.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  STAT3

• CAS Number :

  [73360-56-2]