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β-Eudesmol

CAT: 0804-HY-N6018-04Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N6018-04Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
β-Eudesmol has anticancer and anti-inflammatory activities. Beta-Eudesmol can induce apoptosis. β-Eudesmol is a neostigmine antagonist. β-Eudesmol can antagonize neostigmine-induced neuromuscular failure. β-Eudesmoll can be used in the study of sepsis diseases. β-Eudesmol is a sesquiterpene-like compound that can be extracted from the rhizome of Atractylodes lancea[1][2][3][4].
CAS Number
473-15-4
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Caspase; Reactive Oxygen Species (ROS) ; SOD; TNF Receptor
Type
Natural Products
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/beta-eudesmol.html
Purity
99.49
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL
Smiles
C[C@]12[C@@](C(CCC2)=C)([H])C[C@H](C(C)(O)C)CC1
Molecular Formula
C15H26O
Molecular Weight
222.37
Precautions
H302, H315, H319, H335
References & Citations
[1]Ma EL, et al. Beta-eudesmol suppresses tumour growth through inhibition of tumour neovascularisation and tumour cell proliferation. J Asian Nat Prod Res. 2008 Jan-Feb;10 (1-2) :159-67.|[2] Xu Q, et al. Protective effects of β-eudesmol against septic liver injury via inhibition of NF-κB signaling[J]. Tropical Journal of Pharmaceutical Research, 2022, 21 (6) : 1183-1188.|[3]Chiou LC, et al. Antagonism by beta-eudesmol of neostigmine-induced neuromuscular failure in mouse diaphragms. Eur J Pharmacol. 1992 Jun 5;216 (2) :199-206.|[4]Hoang D M, et al. Eudesmols induce apoptosis through release of cytochrome c in HL-60 cells[J]. Natural Product Sciences, 2010, 16 (2) : 88-92.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported

Chemical Information

Beta-Eudesmol

Beta-eudesmol is a carbobicyclic compound that is trans-decalin substituted at positions 2, 4a, and 8 by 2-hydroxypropan-2-yl, methyl and methylidene groups, respectively (the 2R,4aR,8aS-diastereoisomer). It has a role as a volatile oil component. It is a tertiary alcohol, a carbobicyclic compound and a eudesmane sesquiterpenoid.

CAS Number473-15-4
PubChem CID91457
IUPAC Name2-[(2R,4aR,8aS)-4a-methyl-8-methylidene-1,2,3,4,5,6,7,8a-octahydronaphthalen-2-yl]propan-2-ol
Molecular FormulaC15H26O
Molecular Weight222.37
XLogP3.7
Topological Polar Surface Area20.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count1
Heavy Atom Count16
Formal Charge0
Complexity292
SMILES
C[C@]12CCCC(=C)[C@@H]1C[C@@H](CC2)C(C)(C)O
InChI
InChI=1S/C15H26O/c1-11-6-5-8-15(4)9-7-12(10-13(11)15)14(2,3)16/h12-13,16H,1,5-10H2,2-4H3/t12-,13+,15-/m1/s1
InChIKey
BOPIMTNSYWYZOC-VNHYZAJKSA-N
Chemical Structure
2D Structure
2D structure of Beta-Eudesmol
CAS: 473-15-4
CID: 91457
Formula: C15H26O
MW: 222.37
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight222.37
XLogP33.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count1
Exact Mass222.198365449
Monoisotopic Mass222.198365449
Topological Polar Surface Area20.2 Ų
Heavy Atom Count16
Formal Charge0
Complexity292
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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