IL17A Protein (Native, Human)

• Abbreviation :

  IL17A

• Synonyms :

  CTLA-8, CTLA8, IL-17, IL-17A, IL17, ILA17

• Host :

  E. coli

• Tag :

  Native

• Endotoxin :

  < 1.0 EU per μg of the protein as determined by the LAL method.

• Purity :

  ≥ 95 % as determined by SDS-PAGE

• Bioactivity :

  1.Measured by its ability to induce IL-6 secretion by NIH‐3T3 mouse embryonic fibroblast cells in the presense of 20 ng/mL TNFα. The ED50 for this effect is 0.5-2.5 ng/mL. 2.Recombinant Human IL-17RA Protein, hFc Tag (Cat. No. 10895-H02H) captured on Protein A chip can bind Recombinant Human IL-17A Protein (Cat. No. 12047-HNAE) with an affinity constant of 0.190 nM as determined in an SPR assay (Biacore 8K) (Routinely tested) . 3.Anti-IL17A (Research Grade Ixekiz*mab Biosimilar) captured on Protein A chip, can bind Recombinant Human IL-17A Protein (Cat. No. 12047-HNAE) with an affinity constant of 24.450 pM pM as determined in an SPR assay (Biacore T200) (Routinely tested) . 4.Anti-IL17A (Research Grade Secukin*mab Biosimilar) captured on Protein A chip, can bind Recombinant Human IL-17A Protein (Cat. No. 12047-HNAE) with an affinity constant of 65.890 pM as determined in an SPR assay (Biacore T200) (Routinely tested) .

• Function :

  Ile20-Ala155

• Molecular Weight :

  The recombinant human IL17A consists of 137 amino acids and predicts a molecular mass of 15.7 KDa.

• Species :

  Human