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Anti-SETD1B Antibody

CAT: 0519-A08609Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0519-A08609Size:100 µL
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Background
SETD1B, also named as KMT2G. Set1B associates with a about 450 kDa complex that contains all five non-catalytic components of the Set1A complex, including CFP1, Rbbp5, Ash2, Wdr5, and Wdr82. The complex is a histone methyltransferase that produces trimethylated histone H3 at Lys4. Set1B is widely expressed, and localize to a largely non-overlapping set of euchromatic nuclear speckles, suggesting that Set1B bind to a unique set of target genes and thus make non-redundant contributions to the epigenetic control of chromatin structure and gene expression (PMID: 17355966) . The antibody is specific to SETD1B and, in westernbloting experiments, two specific bands can be detected, about 250 kDa, 450 kDa respectively, in addition, a unknown band around 70 kDa. This antibody is a rabbit polyclonal antibody raised against a region of human SETD1B.
Description
Boster Bio Anti-SETD1B Antibody catalog # A08609. Tested in WB, IHC, ICC, IF, IP, ELISA applications. This antibody reacts with Human, Mouse.
Synonyms
Lysine N-methyltransferase 2G; KMT2G; KIAA1076; hSET1B; Histone-lysine N-methyltransferase SETD1B
Gene Name
SETD1B
UniProt
Q9UPS6
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Peptide
Clonality
Polyclonal
Applications
WB, IHC, ICC, IF, IP, ELISA
Purification
Immunogen affinity purified.
Concentration
500 μg/mL
Form
Liquid
Storage Conditions
12 months from date of receipt, -20°C as supplied. 6 months 2 to 8°C after reconstitution. Avoid repeated freezing and thawing.
Gene Name Synonym
SET domain containing 1B, histone lysine methyltransferase
Protein Name
Histone-lysine N-methyltransferase SETD1B
Contents
500 μg/mL antibody with PBS,0.02% NaN3, 1 mg BSA and 50% glycerol.

UniProtKB · Q9UPS6

Histone-lysine N-methyltransferase SETD1B

SET1B_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9UPS6
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SETD1B
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.1.1.364
Processing
—
Secondary accessions
F6MFW1
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorChromatin regulatorMethyltransferaseRNA-bindingTransferase

Coding sequence diversity

Alternative splicing

Cellular component

ChromosomeCytoplasmNucleus

Domain

Coiled coil

Disease

Disease variantEpilepsyIntellectual disability

PTM

Phosphoprotein

Ligand

S-adenosyl-L-methionine

Biological process

TranscriptionTranscription regulation

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