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Anti-ULK4 Antibody

CAT: 0519-A08552Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0519-A08552Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ULK4 belongs to the Ser/Thr protein kinase superfamily and plays a role in the ATP-dependent phosphorylation of target proteins (1) . Knockout of ULK genes results in a severe defect in the autophagy pathway (2) . ULK4, like the other Unc-51-like kinases such as ULK1, ULK2 and ULK3, is highly conserved among eukaryotes (3) . ULK4 has been implicated as a gene involved in the development of hydrocephalus (3) . This neurologic disorder is being used in animal models to elucidate factors responsible for the excessive accumulation of cerebrospinal fluid in hydrocephalic humans (4) .
Description
Boster Bio Anti-ULK4 Antibody (Catalog # A08552) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.
Synonyms
FAM7C1, REC01035Unc-51-like kinase 4
Gene Name
ULK4
UniProt
Q96C45
Host
Rabbit
Reactivity
Human, Mouse
Cross Reactivity
ULK4 antibody is human and mouse reactive. Multiple isoforms of ULK4 are known to exist.
Immunogen
ULK4 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human ULK4. The immunogen is located within amino acids 1120 - 1170 of ULK4.
Clonality
Polyclonal
Tissue Specificity
Expressed in the brain, mainly in postmitotic neurons, including GABAergic neurons, but not in astrocytes (at protein level) .
Applications
ELISA, WB, IHC-P, IF
Field of Research
Autophagy
Purification
ULK4 antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL
Form
Liquid
Function
May be involved in the remodeling of cytoskeletal components, such as alpha-tubulin, and in this way regulates neurite branching and elongation, as well as cell motility.
Storage Conditions
ULK4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Observed Molecular Weight
142442 MW
Gene Name Synonym
Unc-51 like kinase 4
Protein Name
Unc-51 like kinase 4
Isotype
IgG
Contents
ULK4 antibody is supplied in PBS containing 0.02% sodium azide.

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