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Anti-ULK2 Antibody

CAT: 0519-A05219Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0519-A05219Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Boster Bio Anti-ULK2 Antibody catalog # A05219. Tested in WB, ELISA applications. This antibody reacts with Human, Mouse, Rat.
Synonyms
Serine/threonine-protein kinase ULK2;2.7.11.1; Unc-51-like kinase 2; ULK2; KIAA0623
Gene Name
ULK2
UniProt
Q8IYT8
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide from human protein at AA range: 930-1000
Clonality
Polyclonal
Applications
WB, ELISA
Purification
The antibody was affinity-purified from rabbit anti-serum by affinity-chromatography.
Concentration
1 mg/mL
Form
Liquid
Function
Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons. .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
112694 MW
Gene Name Synonym
Serine/threonine-protein kinase ULK2
Subcellular Location
Cytoplasmic vesicle membrane ; Peripheral membrane protein . Localizes to pre- autophagosomal membrane.
Isotype
IgG
Contents
PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.

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