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Anti-ULK2 Antibody

CAT: 0519-A05219-1Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0519-A05219-1Size:0.1 mg
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Background
ULK2, also known as ATG1B, is a key serine/threonine protein kinase probably acting at the most upstream step of autophagosome formation. Knockout of ULK2 results in a severe defect in the autophagy pathway. ULK2 is highly conserved among eukaryotes and shows high homology with its related protein ULK1. Both ULK1 and ULK2 form a complex with ATG13 and FIP200 that mediates TOR signaling and is essential for autophagy. Like ULK1, ULK2 is also thought to be involved in early neuronal growth and differentiation.
Description
Boster Bio Anti-ULK2 Antibody (Catalog # A05219-1) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.
Synonyms
ATG1B, Unc51.2, KIAA0623, Unc-51-like kinase 2
Gene Name
ULK2
UniProt
Q8IYT8
Host
Rabbit
Reactivity
Human
Cross Reactivity
At least two isoforms of ULK2 are known to exist; this antibody will detect both isoforms. ULK2 antibody is predicted to not cross-react with ULK1.
Immunogen
ULK2 antibody was raised against a 17 amino acid peptide near the center of human ULK2 . The immunogen is located within amino acids 480 - 530 of ULK2.
Clonality
Polyclonal
Applications
ELISA, WB, IHC-P, IF
Field of Research
Autophagy
Purification
ULK2 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL
Form
Liquid
Function
Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons.
Molecular Weight
112694 MW
Shipping Conditions
Available
Storage Conditions
ULK2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Fragment
IgG
Other Gene Names
Unc-51-like kinase 2 (C. elegans)
Subcellular Location
Cytoplasmic vesicle membrane
Prediction Reactivity
Mouse
Protein Name
Unc-51-like kinase 2 (C. elegans)

UniProtKB · Q8IYT8

Serine/threonine-protein kinase ULK2

ULK2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8IYT8
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ULK2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.11.1
Processing
—
Secondary accessions
A8MY69, O75119
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Ligand

ATP-bindingNucleotide-binding

Biological process

AutophagyNeurogenesis

Cellular component

Cytoplasmic vesicleMembrane

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

PTM

Phosphoprotein

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