Products for Research Use Only
RegisterLogin

Recombinant Human CNTF Protein

CAT: 0519-R00609Size: 100 µg/VialDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0519-R00609Size:100 µg/Vial
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Ciliary Neurotrophic Factor (CNTF) is a cytokine belonging to the Interleukin 6 (IL-6) family, which also includes IL-6, Oncostatin M, Leukemia Inhibitory Factor (LIF), and Cardiotrophin-1. Structurally, CNTF resembles a four-helix bundle composition, similar to the other members of the IL-6 family. The receptor for CNTF is composed of three parts: a gp130-like subunit common in the IL-6 receptor family, a LIF Receptor β subunit, and a CNTF specific α receptor subunit. Upon binding to the CNTF, the β subunit of the CNTF receptorwill undergo tyrosine phosphorylation, and activate the intracellular JAK/STAT pathway. The main function of CNTF in vivo is to promote the differentiation and survival of a variety of neurons and glial cells, including sympathetic precursor cells and spinal motor neurons. Recombinant human Ciliary Neurotrophic Factor (rhCNTF) produced in E. coli is a single non-glycosylated polypeptide chain containing 199 amino acids. A fully biologically active molecule, rhCNTF has a molecular mass of 22.8 kDa analyzed by reducing SDS-PAGE.
Gene Name
CNTF
Gene ID
1270
UniProt
P26441
Reactivity
Human
Source
E. coli His12-Met200
Purification
>95%, by SDS-PAGE quantitative densitometry by Coomassie? Blue Staining.
Endotoxin
Less than 1 EU/μg of rhCNTF as determined by LAL method.
Form
Lyophilized
Storage Conditions
Lyophilized recombinant human Ciliary Neurotrophic Factor (rhCNTF) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhCNTF remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.
Calculated Molecular Weight
21.7KD
AA Sequence
HRRDL CSRSI WLARK IRSDL TALTE SYVKH QGLNK NINLD SADGM PVAST DQWSE LTEAE RLQEN LQAYR TFHVL LARLL EDQQV HFTPT EGDFH QAIHT LLLQV AAFAY QIEEL MILLE YKIPR NEADG MPINV GDGGL FEKKL WGLKV LQELS QWTVR SIHDL RFISS HQTGI PARGS HYIAN NKKM
Contents
Lyophilized after extensive dialysis against PBS.

UniProtKB · P26441

Ciliary neurotrophic factor

CNTF_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P26441
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CNTF
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
CNTF
EC number
—
Processing
—
Secondary accessions
B2RAB2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Cellular component

CytoplasmSecreted

Molecular function

Developmental proteinGrowth factor

Biological process

DifferentiationNeurogenesis

Related Products

CatalogName
PROTP26441-500ugHuman CNTF Recombinant Protein
PROTP26441-20ugHuman CNTF Recombinant Protein
PROTP26441-100ugHuman CNTF Recombinant Protein
PROTP26992CNTF Receptor alpha (CNTFR) (NM_147164) Human Recombinant Protein
PROTP20294-1Recombinant Rat CNTF Protein
PROTP20294-10ugRat CNTF Recombinant Protein
PROTP20294-250ugRat CNTF Recombinant Protein
PROTP20294-50ugRat CNTF Recombinant Protein
PROTQ08406-50ugRat CNTF R alpha Recombinant Protein
PROTQ08406-10ugRat CNTF R alpha Recombinant Protein

Alternative Products

CatalogName
TMPJ-00081-01CNTF Protein, Human, Recombinant
PPT-11938Human CNTF Recombinant Protein
ATGP1156-100Recombinant human CNTF protein
OPCA00622-1MGCNTF Recombinant Protein (Human)
TP724653CNTF Human Recombinant Protein

Popular Products