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Citric acid

CAT: 0804-HY-N1428-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N1428-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries[1][2][3][4].
CAS Number
77-92-9
UNSPSC
12352211
Hazard Statement
H319, H335
Target
Apoptosis; Bacterial; Endogenous Metabolite
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection; Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Citric_acid.html
Concentration
10mM
Purity
99.93
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
OC(CC(CC(O)=O)(C(O)=O)O)=O
Molecular Formula
C6H8O7
Molecular Weight
192.12
Precautions
H319, H335
References & Citations
[1]Chen X, et al. Study on injury effect of food additive citric acid on liver tissue in mice. Cytotechnology. 2014 Mar;66 (2) :275-82.|[2]Chen X, Lv Q, Liu Y, Deng W. Effects of the food additive, citric acid, on kidney cells of mice. Biotech Histochem. 2015 Jan;90 (1) :38-44. |[3]Ying TH, et al. Citric acid induces cell-cycle arrest and apoptosis of human immortalized keratinocyte cell line (HaCaT) via caspase- and mitochondrial-dependent signaling pathways. Anticancer Res. 2013 Oct;33 (10) :4411-20.|[4]Ciriminna R, et al. Citric acid: emerging applications of key biotechnology industrial product. Chem Cent J. 2017 Mar 8;11:22.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Natural Products
Clinical Information
Launched
Citation 01
Food Chem. 2023 Mar 30;405 (Pt A) :134807.|Food Chem. 2025 May 31:489:144992.|J Sep Sci. 2025 Nov;48 (11) :e70312.|Mol Cancer. 2025 Oct 2;24 (1) :238.|Nature. 2025 Jul;643 (8070) :192-200.|New J Chem. 03 Aug 2022.|Adv Sci (Weinh) . 2025 May 21:e2505359.|Adv Sci (Weinh) . 2025 Nov 6:e07384.|Adv Sci (Weinh) . 2025 Nov 7:e18323.|Bioengineered. 2021 Dec;12 (2) :11610-11621.|Biol Trace Elem Res. 2024 Feb;202 (2) :701-712.|Biol Trace Elem Res. 2025 Jun 13.|Biomed Pharmacother. 2023 Oct:166:115333.|bioRxiv. 2025 Jul 24:2025.07.24.666650.|Drug Des Devel Ther. 2024 Feb 1:18:259-275.|Front Immunol. 2024 Oct 1:15:1397727.|Front Mol Biosci. 2022 Jul 22:9:952608.|Int J Biol Sci. 2024 Aug 6;20 (11) :4222-4237.|J Biochem Mol Toxicol. 2025 Oct;39 (10) :e70484.|mBio. 2025 Mar 24:e0012725.|Oxid Med Cell Longev. 2022 Apr 25;2022:3846217.|Phytomedicine. 2025 Apr 5:141:156702.|Res Sq. 2025 Aug 08.|Research Square Preprint. 2021 Jul.|Bone. 2025 Jan 28:193:117411.|Regen Biomater. 2024 Aug 22:11:rbae098.|Insect Biochem Mol Biol. 2023 Jun:157:103958.|J Exp Clin Cancer Res. 2025 Jul 8;44 (1) :195.|J Virol. 2023 Jul 27;97 (7) :e0051223.|Mol Ther. 2025 Nov 7:S1525-0016 (25) 00870-6.

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