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BBT

CAT: 0804-HY-Q40876-03Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-Q40876-03Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BBT is an enhancer of impaired glucose-stimulated insulin secretion (GSIS). BBT exhibits anti-hyperglycemia activity, and protects β-cells from cytokine- or streptozotocin (STZ ) -induced cell death in type 2 diabetes models. BBT acts function via cAMP/PKA and long-lasting (L-type) voltage-dependent Ca2+ channel/CaMK2 pathway[1].
CAS Number
445000-45-3
UNSPSC
12352005
Target
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/bbt.html
Purity
99.71
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
C1(=CC=C(Br)S1)C(=O)NC1=CC=CC=C1C(C1C=CC=CC=1)=O
Molecular Formula
C18H12BrNO2S
Molecular Weight
386.27
References & Citations
[1]Yao XG, et al. BBT improves glucose homeostasis by ameliorating -cell dysfunction in type 2 diabetic mice. J Endocrinol. 2015 Mar;224 (3) :327-41.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Dedicated for Diverse Library
Clinical Information
No Development Reported

Chemical Information

N-(2-benzoylphenyl)-5-bromo-2-thiophenecarboxamide

has hypoglycemic activity; structure in first source

CAS Number445000-45-3
PubChem CID1008832
IUPAC NameN-(2-benzoylphenyl)-5-bromothiophene-2-carboxamide
Molecular FormulaC18H12BrNO2S
Molecular Weight386.3
XLogP5.7
Topological Polar Surface Area74.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count23
Formal Charge0
Complexity439
SMILES
C1=CC=C(C=C1)C(=O)C2=CC=CC=C2NC(=O)C3=CC=C(S3)Br
InChI
InChI=1S/C18H12BrNO2S/c19-16-11-10-15(23-16)18(22)20-14-9-5-4-8-13(14)17(21)12-6-2-1-3-7-12/h1-11H,(H,20,22)
InChIKey
FCSCANHTNNHZOH-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(2-benzoylphenyl)-5-bromo-2-thiophenecarboxamide
CAS: 445000-45-3
CID: 1008832
Formula: C18H12BrNO2S
MW: 386.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight386.3
XLogP35.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass384.97721
Monoisotopic Mass384.97721
Topological Polar Surface Area74.4 Ų
Heavy Atom Count23
Formal Charge0
Complexity439
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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