Rabbit Polyclonal Antibody to RPC3

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.Wang Z., Genes Dev. 11:1315-1326 (1997) .Kuwana M., Arthritis Rheum. 46:2742-2747 (2002) .Hsieh Y.-J., Mol. Cell. Biol. 19:7697-7704 (1999) .

DNA-directed RNA polymerase III subunit RPC3; RNA polymerase III subunit C3; DNA-directed RNA polymerase III subunit C; DNA-directed III 62 kDa polypeptide; RPC62

Q9BUI4

Human

Synthesized peptide derived from internal of human RPC3.

WB

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Purified antibody in PBS with 0.05% sodium azide.

Primary antibody

RPC3