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Rabbit Polyclonal Antibody to Mouse Erbb4

CAT: 1725-P34980-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:1725-P34980-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Specifically binds and is activated by neuregulins, NRG-2, NRG-3, heparin-binding EGF-like growth factor, betacellulin and NTAK. Interaction with these factors induces cell differentiation. Not activated by EGF, TGF-A, and amphiregulin. The C-terminal fragment (CTF) of isoform JMA-A CYT-2 (containing E4ICD2) can stimulate transcription in the presence of YAP1. ERBB4 intracellular domain is involved in the regulation of cell growth. Conflicting reports are likely due at least in part to the opposing effects of the isoform-specific and nuclear-translocated ERBB4 intracellular domains (E4ICD1 and E4ICD2) . Overexpression studies in epithelium show growth inhibition using E4ICD1 and increased proliferation using E4ICD2. E4ICD2 has greater in vitro kinase activity than E4ICD1. The kinase activity is required for the nuclear translocation of E4ICD2 (By similarity) .
Product Name Alternative
Receptor tyrosine-protein kinase erbB-4, Proto-oncogene-like protein c-ErbB-4, ERBB4 intracellular domain, 4ICD, E4ICD, s80HER4, Erbb4, Mer4
Swiss Prot
Q61527
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
This Mouse Erbb4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1160-1188 amino acids from the C-terminal region of mouse Erbb4.
Clonality
Polyclonal
Applications
WB
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Formulation
Purified antibody in PBS with 0.05% sodium azide.
Antibody Type
Primary antibody
Protein Name
Mouse Erbb4
Bands Size
146.9kDa

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