Thalidomide-O-amido-C4-NH2 (hydrochloride)

• UNSPSC Description:

  Thalidomide-O-amido-C4-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].

• Target Antigen:

  Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Autophagy;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/thalidomide-o-amido-c4-nh2-hydrochloride.html

• Purity:

  98.11

• Solubility:

  DMSO : 250 mg/mL (ultrasonic)

• Smiles:

  NCCCCNC(COC1=C(C(N2C(CCC3=O)C(N3)=O)=O)C(C2=O)=CC=C1)=O.Cl

• Molecular Weight:

  438.86

• References & Citations:

  [1]Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins withPicomolar Cellular Potencies and Capable of Achieving Tumor Regression.J Med Chem. 2018 Jan 25;61(2):462-481.|[2]James Bradner, et al. Methods to induce targeted protein degradation through bifunctional molecules. WO 2017024317 A2.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, stored under nitrogen, away from moisture)

• Clinical Information:

  No Development Reported

• CAS Number:

  2245697-86-1