Apicidin D2

• Description:

  Apicidin D2 (Compound 4), a fungal metabolite, is a Accessory gene regulator A (AgrA) quorum-sensing inhibitor. Apicidin D2 has anti-virulence activity. Apicidin D2 suppresses MRSA agr activation and shows potent inhibitory activities against all agr types in a nonbiocidal manner. Apicidin D2 can be used for MRSA infections research[1].

• UNSPSC:

  12352100

• Target:

  Bacterial; Endogenous Metabolite

• Related Pathways:

  Anti-infection; Metabolic Enzyme/Protease

• Field of Research:

  Infection

• Smiles:

  O=C1N2[C@@H](C(N[C@@H](CCCCC[C@@H](O)CC)C(N[C@@H](CC3=CN(OC)C4=C3C=CC=C4)C(N[C@H]1[C@@H](CC)C)=O)=O)=O)CCCC2

• Molecular Formula:

  C34H51N5O6

• Molecular Weight:

  625.80

• References & Citations:

  [1]Parlet CP, et al. Apicidin Attenuates MRSA Virulence through Quorum-Sensing Inhibition and Enhanced Host Defense. Cell Rep. 2019 Apr 2;27 (1) :187-198.e6.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [177562-78-6]