Apicidin C

• Description:

  Apicidin C (Compound 5a) is a cyclic tetrapeptide. Apicidin C has an antiprotozoal and antimalarial activity against Eimeria tenella (IC50: 6 nM) by reversibly inhibiting HDAC acyivity. Apicidin C can be used for malaria infections research[1].

• UNSPSC:

  12352005

• Target:

  HDAC; Parasite

• Related Pathways:

  Anti-infection; Cell Cycle/DNA Damage; Epigenetics

• Field of Research:

  Infection

• Smiles:

  CON1C2=CC=CC=C2C(C[C@H]3C(N[C@H](C(N4[C@@](CCCC4)([H])C(N[C@H](C(N3)=O)CCCCCC(CC)=O)=O)=O)C(C)C)=O)=C1

• Molecular Formula:

  C33H47N5O6

• Molecular Weight:

  609.76

• References & Citations:

  [1]Singh SB, et al. Structure, histone deacetylase, and antiprotozoal activities of apicidins B and C, congeners of apicidin with proline and valine substitutions. Org Lett. 2001 Sep 6;3 (18) :2815-8.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  [366448-28-4]