7a-Hydroxyfrullanolide

• Description :

  7a-Hydroxyfrullanolide has anticancer properties. 7a-Hydroxyfrullanolide reduces polymerization of α-, β-tubulin. 7a-Hydroxyfrullanolide preferrs to bind to β-tubulin over α-tubulin. 7a-Hydroxyfrullanolide also triggers DNA damage response arrests cells in the G2/M-phase. 7a-Hydroxyfrullanolide is an eudesmanolide sesquiterpene lactone (SL) and can be isolated from the flowering plants of the Asteraceae family[1].

• UNSPSC :

  12352005

• Target :

  Microtubule/Tubulin

• Related Pathways :

  Cell Cycle/DNA Damage; Cytoskeleton

• Field of Research :

  Cancer

• Smiles :

  O[C@]12[C@](OC(C2=C)=O)([H])C3=C(C)CCC[C@@]3(CC1)C

• Molecular Formula :

  C15H20O3

• Molecular Weight :

  248.32

• References & Citations :

  [1]Chimplee S, et al. Anticancer mechanism of 7-α-hydroxyfrullanolide on microtubules and computational prediction of its target binding in triple-negative breast cancer cells. PeerJ. 2022 May 27;10:e13508.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [105578-87-8]