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Melagatran-d11

CAT: 0804-HY-W743984Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W743984Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Melagatran-d11 is the deuterium labeled Melagatran. Melagatran is a direct and orally active inhibitor of thrombin, without interacting with any other enzymes in the coagulation cascade or fibrinolytic enzymes aside from thrombin. Melagatran does not require endogenous co-factors for its antithrombin effect and may help to alleviate some of the damaging effects of endotoxemia[1]. Melagatran has the potential to provide a rational approach in the prevention of arterial occlusion[2].
UNSPSC
12352005
Target
Isotope-Labeled Compounds; Thrombin
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Cardiovascular Disease
Smiles
O=C(NCC1=CC=C(C=C1)C(N)=N)[C@@H]2CCN2C([C@@H](C3(C([2H])(C([2H])(C([2H])(C([2H])(C3([2H])[2H])[2H])[2H])[2H])[2H])[2H])NCC(O)=O)=O
Molecular Formula
C22H20D11N5O4
Molecular Weight
440.58
References & Citations
[1]Eriksson M, et al. Effects of melagatran, a novel direct thrombin inhibitor, during experimental septic shock. Expert Opin Investig Drugs. 2000 May;9 (5) :1129-37.|[2]Mehta JL, et al. Melagatran, an oral active-site inhibitor of thrombin, prevents or delays formation of electrically induced occlusive thrombus in the canine coronary artery. J Cardiovasc Pharmacol. 1998 Mar;31 (3) :345-51.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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