Daurisoline-d11
CAT:
804-HY-N0221S2
Size:
1 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Daurisoline-d11
- UNSPSC Description: Daurisoline-d11 is the deuterium labeled Daurisoline (HY-N0221). Daurisoline is a bis-benzylisoquinoline alkaloid that can be isolated from Menispermum dauricum and Rhizoma Menispermi. Daurisoline exerts a blocking effect on hERG and has antiarrhythmic effects. Daurisoline is a potent autophagy blocker that can be used for the research of cancer[1][2].
- Target Antigen: Autophagy; Isotope-Labeled Compounds; Potassium Channel
- Type: Isotope-Labeled Compounds
- Related Pathways: Autophagy;Membrane Transporter/Ion Channel;Others
- Applications: COVID-19-immunoregulation
- Field of Research: Cancer
- Solubility: 10 mM in DMSO
- Smiles: OC1=C(C2=C(CCN([C@@H]2CC3=C(C([2H])=C(C(OC4=C(C([2H])=C(C([2H])=C4[2H])C[C@H]5N(CCC6=C5C([2H])=C(C(OC)=C6[2H])OC)C)[2H])=C3[2H])O)[2H])C)C([2H])=C1OC)[2H]
- Molecular Weight: 621.81
- References & Citations: [1]Liu Q, et al. Effect of daurisoline on HERG channel electrophysiological function and protein expression. J Nat Prod. 2012 Sep 28;75(9):1539-45. |[2]Wu MY, et al. Natural autophagy blockers, dauricine (DAC) and daurisoline (DAS), sensitize cancer cells to camptothecin-induced toxicity. Oncotarget. 2017 Sep 8;8(44):77673-77684.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported