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Picolinafen

CAT: 0804-HY-W711035Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W711035Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Picolinafen is a pyridine-class herbicide that acts as a phytoene desaturase (PDS) inhibitor. Picolinafen effectively controls broadleaf weeds and disrupts carotenoid biosynthesis. Picolinafen exhibits cytotoxicity to porcine trophectoderm (pTr) and luminal epithelial (pLE) cells. Picolinafen induces (ROS accumulation, calcium depletion, and activates (MAPK and PI3K signaling pathways, leading to decreased cell viability, increased apoptosis, impaired migration, and altered expression of implantation-related genes. Picolinafen has an LD50 value of 2.7 mg/kg in mammals and 7 μg/L in fish. Picolinafen exhibits toxic effects during zebrafish embryogenesis[1][2].
CAS Number
137641-05-5
Product Name Alternative
AC 900001
UNSPSC
12352005
Hazard Statement
H410
Target
Apoptosis; Calcium Channel; Cytochrome P450; p38 MAPK; PI3K; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C(C1=NC(OC2=CC(C(F)(F)F)=CC=C2)=CC=C1)NC3=CC=C(C=C3)F
Molecular Formula
C19H12F4N2O2
Molecular Weight
376.30
Precautions
P273-P391-P501
References & Citations
[1]Park W, et al. ROS accumulation and calcium depletion, leading to apoptosis in porcine embryonic trophectoderm and uterine luminal epithelial cells during the peri-implantation period. Theriogenology. 2023 Apr 15;201:12-23.|[2]Lee JY, et al. Picolinafen exerts developmental toxicity via the suppression of oxidative stress and angiogenesis in zebrafish embryos. Pestic Biochem Physiol. 2021 Jan;171:104734.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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