Products for Research Use Only
RegisterLogin

Norfenfluramine (hydrochloride)

CAT: 0804-HY-W707158-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-W707158-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Norfenfluramine hydrochloride ((±) -Norfenfluramine hydrochloride) is the primary metabolite of Fenfluramine, formed through N-dealkylation of Fenfluramine. Norfenfluramine hydrochloride is also a potent anorexiant. Norfenfluramine hydrochloride can regulate serotonergic neurotransmission. In addition, Norfenfluramine hydrochloride exhibits sedative effects after acute administration[1][2].
CAS Number
673-18-7
Product Name Alternative
(±) -Norfenfluramine (hydrochloride)
UNSPSC
12352005
Target
Drug Metabolite
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
NC(CC1=CC=CC(C(F)(F)F)=C1)C.Cl
Molecular Formula
C10H13ClF3N
Molecular Weight
239.67
References & Citations
[1]Martin P, et al. In vitro evaluation of fenfluramine and norfenfluramine as victims of drug interactions. Pharmacol Res Perspect. 2022 Jun;10 (3) :e00958.|[2]Goudie AJ, et al. Chronic anorexic and behavioural effects of the fenfluramine metabolite, norfenfluramine: an evaluation of its role in the actions of fenfluramine. Psychopharmacologia. 1974;38 (1) :67-74.|[3]Rothman RB, Clark RD, Partilla JS, Baumann MH. (+) -Fenfluramine and its major metabolite, (+) -norfenfluramine, are potent substrates for norepinephrine transporters. J Pharmacol Exp Ther. 2003;305 (3) :1191-1199.|[4]Erenburg N, Hamed R, Shaul C, Perucca E, Bialer M. Comparative activity of the enantiomers of fenfluramine and norfenfluramine in rodent seizure models, and relationship with their concentrations in plasma and brain. Epilepsia. 2023;64 (6) :1673-1683.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Norfenfluramine hydrochloride
CAS Number673-18-7
PubChem CID120765
IUPAC Name1-[3-(trifluoromethyl)phenyl]propan-2-amine;hydrochloride
Molecular FormulaC10H13ClF3N
Molecular Weight239.66
Topological Polar Surface Area26
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count15
Formal Charge0
Complexity179
SMILES
CC(CC1=CC(=CC=C1)C(F)(F)F)N.Cl
InChI
InChI=1S/C10H12F3N.ClH/c1-7(14)5-8-3-2-4-9(6-8)10(11,12)13;/h2-4,6-7H,5,14H2,1H3;1H
InChIKey
PIDLOFBRTWNFAR-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Norfenfluramine hydrochloride
CAS: 673-18-7
CID: 120765
Formula: C10H13ClF3N
MW: 239.66
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight239.66
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass239.0688616
Monoisotopic Mass239.0688616
Topological Polar Surface Area26 Ų
Heavy Atom Count15
Formal Charge0
Complexity179
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-W131725-01(+) -Norfenfluramine
HY-118010B(-) -Norfenfluramine
HY-118010Norfenfluramine
HY-B0500BAlverine (hydrochloride)
HY-N14912β-Prumycin hydrochloride
HY-N0300A-01Tetrahydropalmatine (hydrochloride)
HY-172541LN6023 (hydrochloride)
HY-172070-01Metaescaline (hydrochloride)
HY-170052-01α-Isopropylaminohexanophenone (hydrochloride)
HY-168824-01Cypenamine (hydrochloride)

Alternative Products

CatalogName
T72114-01(+) -Norfenfluramine hydrochloride
GTR19240970-01Norfenfluramine hydrochloride
CS-T-82832(S) -Norfenfluramine Hydrochloride
TRC-N680980-250MG(S)-Norfenfluramine Hydrochloride
CS-CX-00613Norfenfluramine-D6 hydrochloride
TRC-N680985-5MG(R)-Norfenfluramine Hydrochloride
CS-T-83109(R) -Norfenfluramine Hydrochloride
465722-01S-Norfenfluramine Hydrochloride discontinued
TRC-H825265-1Grac Hydroxyethyl Norfenfluramine Hydrochloride
464047-01(R) -Norfenfluramine Hydrochloride discontinued

Popular Products