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(+) -Norfenfluramine

CAT: 0804-HY-W131725-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W131725-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(+) -Norfenfluramine a major hepatic metabolite of (+) -fenfluramine, is a selective 5-HT2B receptor agonist (Ki: 11.2 nM) . (+) -Norfenfluramine potently stimulates the hydrolysis of inositol phosphates and increases intracellular Ca2+. (+) -Norfenfluramine can be used for the research of primary pulmonary hypertension and valvular heart disease[1].
CAS Number
19036-73-8
Product Name Alternative
D-Norfenfluramine
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/plus-norfenfluramine.html
Purity
99.92
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C=1(C=C(C=CC1)C(F)(F)F)C[C@H](C)N
Molecular Formula
C10H12F3N
Molecular Weight
203.20
Precautions
H315, H319, H320
References & Citations
[1]Wei Ni, et al. The 5-hydroxytryptamine2A receptor is involved in (+) -norfenfluramine-induced arterial contraction and blood pressure increase in deoxycorticosterone acetate-salt hypertension. J Pharmacol Exp Ther. 2007 May;321 (2) :485-91. |[2]M Gobbi, et al. In vitro studies on the mechanism by which (+) -norfenfluramine induces serotonin and dopamine release from the vesicular storage pool. Naunyn Schmiedebergs Arch Pharmacol. 1998 Sep;358 (3) :323-7. |[3]R Invernizzi, et al. Is receptor activation involved in the mechanism by which (+) -fenfluramine and (+) -norfenfluramine deplete 5-hydroxytryptamine in the rat brain? Br J Pharmacol. 1982 Mar;75 (3) :525-30. |[4]Erenburg N, Hamed R, Shaul C, Perucca E, Bialer M. Comparative activity of the enantiomers of fenfluramine and norfenfluramine in rodent seizure models, and relationship with their concentrations in plasma and brain. Epilepsia. 2023;64 (6) :1673-1683.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT2 Receptor; α-1 microglobulin

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