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(S) - (-) -Felodipine

CAT: 0804-HY-W700354Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W700354Size:1 Each
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Description
(S) - (-) -Felodipine is a S-enantiomer of Felodipine. (S) - (-) -Felodipine is an antihypertensive agent. Felodipine is a 1,4-dihydropyridine derivative and a vasoselective calcium antagonist. Felodipine can prevent the activation of the vascular effector cells and interfere with the contractile process in vitro. Felodipine lowers mean arterial blood pressure by 20% in dog model. (S) - (-) -Felodipine shows high metabolic rate in rat and dog liver microsomes[1][2].
CAS Number
105618-03-9
UNSPSC
12352005
Target
Calcium Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Metabolic Disease; Cardiovascular Disease
Smiles
CCOC(C1=C(C)NC(C)=C(C(OC)=O)[C@@H]1C2=C(C(Cl)=CC=C2)Cl)=O
Molecular Formula
C18H19Cl2NO4
Molecular Weight
384.25
References & Citations
[1]Eriksson, U. G., et al., (1991) . Stereoselective metabolism of felodipine in liver microsomes from rat, dog, and human. Drug metabolism and disposition: the biological fate of chemicals, 19 (5), 889-894. |[2]Ljung, B. Vascular Selectivity of Felodipine. Drugs 29 (Suppl 2), 46-58 (1985) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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