(R)-(-)-Felodipine-d5

(R)-(-)-Felodipine-d5

• CAS Number: 1217744-87-0
• UNSPSC Description: (R)-(-)-Felodipine-d5 is the deuterium labeled (R)-(-)-Felodipine. (R)-(-)-Felodipine is the S enantiomer of Felodipine. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier[1][2][3].
• Target Antigen: Autophagy; Calcium Channel; Isotope-Labeled Compounds
• Type: Isotope-Labeled Compounds
• Related Pathways: Autophagy;Membrane Transporter/Ion Channel;Neuronal Signaling;Others
• Field of Research: Cardiovascular Disease
• Solubility: 10 mM in DMSO
• Smiles: [2H]C([2H])([2H])C([2H])([2H])OC(C1=C(C)NC(C)=C(C(OC)=O)[C@@]1([H])C2=C(C(Cl)=CC=C2)Cl)=O
• Molecular Weight: 389.28
• References & Citations: [1]Johnson JD, et al. Calcium and calmodulin antagonists binding to calmodulin and relaxation of coronary segments. J Pharmacol Exp Ther. 1983;226(2):330-334.;Siddiqi FH, et al. Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to r|[2]Siddiqi FH, et al. Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing. Nat Commun. 2019 Apr 18;10(1):1817.|[3]Siddiqi FH, et al. Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing. Nat Commun. 2019 Apr 18;10(1):1817.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported