γ-Eudesmol

• Description :

  γ-Eudesmol ((+) -γ-Eudesmol) is a mitochondrial-mediated apoptosis inducer. γ-Eudesmol binds mitochondrial membrane proteins, triggering depolarization of mitochondrial membrane potential and activating caspase cascades. γ-Eudesmol demonstrates cytotoxicity against multiple tumor cell lines (e.g., HepG2, B16-F10) with IC50 values ranging from 8.86-15.15 μg/mL. γ-Eudesmol is promising for research of cancers, such as hepatocellular carcinoma and melanoma[1][2][3].

• Product Name Alternative :

  (+) -γ-Eudesmol

• UNSPSC :

  12352211

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  Apoptosis

• Related Pathways :

  Apoptosis

• Field of Research :

  Cancer

• Smiles :

  C[C@]12C(C[C@@H](CC1)C(C)(O)C)=C(CCC2)C

• Molecular Formula :

  C15H26O

• Molecular Weight :

  222.37

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

• References & Citations :

  [1]Chin YW, et al. Cytotoxic anticancer candidates from terrestrial plants. Anticancer Agents Med Chem. 2009 Oct;9 (8) :913-42.|[2]Bomfim DS, et al. Eudesmol isomers induce caspase-mediated apoptosis in human hepatocellular carcinoma HepG2 cells. Basic Clin Pharmacol Toxicol. 2013 Nov;113 (5) :300-6.|[3]Van Beek T A, et al. Essential oil of Amyris balsamifera[J]. Phytochemistry, 1989, 28 (7) : 1909-1911.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound2

• Clinical Information :

  No Development Reported

• CAS Number :

  [1209-71-8]