γ-Eudesmol

CAT: 0804-HY-W587938Size: 500 µgDry Ice: NoHazardous: No
CAT#:0804-HY-W587938Size:500 µg
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Description
γ-Eudesmol ((+) -γ-Eudesmol) is a mitochondrial-mediated apoptosis inducer. γ-Eudesmol binds mitochondrial membrane proteins, triggering depolarization of mitochondrial membrane potential and activating caspase cascades. γ-Eudesmol demonstrates cytotoxicity against multiple tumor cell lines (e.g., HepG2, B16-F10) with IC50 values ranging from 8.86-15.15 μg/mL. γ-Eudesmol is promising for research of cancers, such as hepatocellular carcinoma and melanoma[1][2][3].
CAS Number
[1209-71-8]
Product Name Alternative
(+) -γ-Eudesmol
UNSPSC
12352211
Hazard Statement
H302-H315-H319-H335
Target
Apoptosis
Related Pathways
Apoptosis
Field of Research
Cancer
Smiles
C[C@]12C(C[C@@H](CC1)C(C)(O)C)=C(CCC2)C
Molecular Formula
C15H26O
Molecular Weight
222.37
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Chin YW, et al. Cytotoxic anticancer candidates from terrestrial plants. Anticancer Agents Med Chem. 2009 Oct;9 (8) :913-42.|[2]Bomfim DS, et al. Eudesmol isomers induce caspase-mediated apoptosis in human hepatocellular carcinoma HepG2 cells. Basic Clin Pharmacol Toxicol. 2013 Nov;113 (5) :300-6.|[3]Van Beek T A, et al. Essential oil of Amyris balsamifera[J]. Phytochemistry, 1989, 28 (7) : 1909-1911.
Shipping Conditions
Room temperature
Scientific Category
Reference compound2
Clinical Information
No Development Reported

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