Probenecid (sodium)

• Description:

  Probenecid sodium is the sodium salt of Probenecid. Probenecid is an effective selective transient receptor potential vanilloid 2 (TRPV2) agonist. Probenecid also inhibits the pannexin 1 channel[1][2][3][4].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Bacterial; HIV; TRP Channel

• Related Pathways:

  Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Concentration:

  10mM

• Purity:

  99.37

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  O=C(C1=CC=C(S(=O)(N(CCC)CCC)=O)C=C1)O[Na]

• Molecular Formula:

  C13H18NNaO4S

• Molecular Weight:

  307.34

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Koch SE, et al. Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation. J Mol Cell Cardiol. 2012 Jul;53 (1) :134-44.|[2]Bakos E, et al. Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions. Mol Pharmacol. 2000 Apr;57 (4) :760-8.|[3]Greene TA, et al. Probenecid inhibits the human bitter taste receptor TAS2R16 and suppresses bitter perception of salicin. PLoS One. 2011;6 (5) :e20123.|[4]Silverman W, et al. Probenecid, a gout remedy, inhibits pannexin 1 channels. Am J Physiol Cell Physiol. 2008 Sep;295 (3) :C761-7.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 4

• Isoform:

  TRPV2

• CAS Number:

  [23795-03-1]