Probenecid-d14

• Description:

  Probenecid-d14 is the deuterium labeled Probenecid. Probenecid is a potent and selective agonist of transient receptor potential vanilloid 2 (TRPV2) channels. Probenecid also inhibits pannexin 1 channels[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302

• Target:

  Bacterial; HIV; Isotope-Labeled Compounds; TRP Channel

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling; Others

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Purity:

  99.0

• Solubility:

  DMSO : 30 mg/mL (ultrasonic; warming)

• Smiles:

  S (N (C (C (C ([2H]) ([2H]) [2H]) ([2H]) [2H]) ([2H]) [2H]) C (C (C ([2H]) ([2H]) [2H]) ([2H]) [2H]) ([2H]) [2H]) (=O) (=O) C1=CC=C (C (O) =O) C=C1

• Molecular Formula:

  C13H5D14NO4S

• Molecular Weight:

  299.45

• Precautions:

  P264-P270-P330-P501

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Koch SE, et al. Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation. J Mol Cell Cardiol. 2012 Jul;53 (1) :134-44.|[3]Bakos E, et al. Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions. Mol Pharmacol. 2000 Apr;57 (4) :760-8.|[4]Greene TA, et al. Probenecid inhibits the human bitter taste receptor TAS2R16 and suppresses bitter perception of salicin. PLoS One. 2011;6 (5) :e20123.|[5]Silverman W, et al. Probenecid, a gout remedy, inhibits pannexin 1 channels. Am J Physiol Cell Physiol. 2008 Sep;295 (3) :C761-7.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  1189657-87-1