Probenecid-d14

CAT: 0804-HY-B0545SSize: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0545SSize:1 mg
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Description
Probenecid-d14 is the deuterium labeled Probenecid. Probenecid is a potent and selective agonist of transient receptor potential vanilloid 2 (TRPV2) channels. Probenecid also inhibits pannexin 1 channels[1][2].
CAS Number
[1189657-87-1]
UNSPSC
12352005
Hazard Statement
H302
Target
Bacterial; HIV; Isotope-Labeled Compounds; TRP Channel
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Purity
99.0
Solubility
DMSO : 30 mg/mL (ultrasonic; warming)
Smiles
S(N(C(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H])C(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H])(=O)(=O)C1=CC=C(C(O)=O)C=C1
Molecular Formula
C13H5D14NO4S
Molecular Weight
299.45
Precautions
P264-P270-P330-P501
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Koch SE, et al. Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation. J Mol Cell Cardiol. 2012 Jul;53 (1) :134-44.|[3]Bakos E, et al. Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions. Mol Pharmacol. 2000 Apr;57 (4) :760-8.|[4]Greene TA, et al. Probenecid inhibits the human bitter taste receptor TAS2R16 and suppresses bitter perception of salicin. PLoS One. 2011;6 (5) :e20123.|[5]Silverman W, et al. Probenecid, a gout remedy, inhibits pannexin 1 channels. Am J Physiol Cell Physiol. 2008 Sep;295 (3) :C761-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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