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12-Ketochenodeoxycholic acid (Standard)

CAT: 0804-HY-W403933RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W403933RSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Afatinib (Standard) is the analytical standard of Afatinib. This product is intended for research and analytical applications. Afatinib (BIBW 2992) is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer[1][2][3][4].
CAS Number
2458-08-4
UNSPSC
12352211
Hazard Statement
H315-H319
Target
Autophagy; Reference Standards
Related Pathways
Autophagy; Others
Field of Research
Metabolic Disease
Smiles
C[C@H](CCC(O)=O)[C@H]([C@]12C)CC[C@@]1([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC2=O
Molecular Formula
C24H38O5
Molecular Weight
406.56
Precautions
P264-P280-P302+P352-P305+P351+P338-P362+P364
References & Citations
[1]Sawada, H. et al. Microbial production of chenodeoxycholic acid precursor, 12-ketochenodeoxycholic acid, from dehydrocholic acid. European Journal of Applied Microbiology and Biotechnology, 10 (1–2), 107–112.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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