Products for Research Use Only
RegisterLogin

GS-829845 (Standard)

CAT: 0804-HY-W394903RSize: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-W394903RSize:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Isatin (Standard) is the analytical standard of Isatin. This product is intended for research and analytical applications. Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC50 of 3 μM. Also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 μM) [1]. Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity[2]. Shows effect on the serotonergic system[3].
CAS Number
1257705-09-1
UNSPSC
12352005
Target
Drug Metabolite; JAK; Reference Standards
Related Pathways
Epigenetics; JAK/STAT Signaling; Metabolic Enzyme/Protease; Others; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer
Smiles
O=S1(CCN(CC1)CC2=CC=C(C3=CC=CC4=NC(N)=NN43)C=C2)=O
Molecular Formula
C17H19N5O2S
Molecular Weight
357.43
References & Citations
[1]Amy Meng, et al. Exposure-response relationships for the efficacy and safety of filgotinib and its metabolite GS-829845 in subjects with rheumatoid arthritis based on phase 2 and phase 3 studies. Br J Clin Pharmacol. 2022 Jul;88 (7) :3211-3221.|[2]Chia-Hsiang Hsueh, et al. Evaluation of the potential drug interactions mediated through P-gp, OCT2, and MATE1/2K with filgotinib in healthy subjects. Clin Transl Sci. 2022 Feb;15 (2) :361-370.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Related Products

CatalogName
HY-W394903-01GS-829845
HY-10081RGS-6201 (Standard)
HY-100844RGS-444217 (Standard)
HY-14308GS-9851
HY-114743GS 283
HY-10081-01GS-6201
HY-145119-01GS-621763
HY-19842-01GS-9667
HY-16593GS-9256
HY-120246GS-5759

Alternative Products

CatalogName
MBS2089799-01Rat Gelsolin (GS) Antibody Pair Kit (with Standard)
MBS2089797-01Bovine Gelsolin (GS) Antibody Pair Kit (with Standard)
MBS2104466-01General Guanosine (GS) Antibody Pair Kit (with Standard)
MBS2098844-01Mouse Gelsolin (GS) Antibody Pair Kit (with Standard)
T67905-01GS-829845
CS-O-62694Filgotinib Metabolite M2 (GS-829845)
MBS131349Selonsertib (GS-4997; GS4997; GS 4997)
M26701-01GS-6201
sc-490337CGS 9973
BA2269-10GS-621763

Popular Products