GCN2 activator-1

CAT: 0804-HY-W319647-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-W319647-01Size:5 mg
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Description
GCN2 activator-1 (Compound 20) is a GCN2 activator. GCN2 activator-1 binds within the ATP-pocket of GCN2 and activates GCN2 in a GCN1-independent manner. GCN2 activator-1 activates Integrated Stress Response (ISR) in cells. GCN2 activator-1 inhibits PKR with an IC50 of 3.75 µM. GCN2 activator-1 can be used for research of pulmonary veno-occlusive disease (PVOD) [1].
CAS Number
[315705-10-3]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Eukaryotic Initiation Factor (eIF) ; Pyruvate Kinase
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Purity
99.69
Solubility
DMSO : 4.55 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
NC1=NC(C)=C(C2=CSC(NC3=NC=CC=N3)=N2)S1
Molecular Formula
C11H10N6S2
Molecular Weight
290.37
Precautions
H302, H315, H319, H335
References & Citations
[1]JiaYi Zhu, et al. A GCN1-independent activator of the kinase GCN2. bioRxiv 2025.06.29.662197
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound2
Clinical Information
No Development Reported
Isoform
EIF2

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Alternative Products

CatalogName
MF-0118870-01GCN2 activator-1
MBS3614872-01GCN2-IN-1
A20412-10GCN2-IN-1 10mg
A20412-5GCN2-IN-1 5mg
A20412-500GCN2-IN-1 500mg
A20412-100GCN2-IN-1 100mg
A20412-1GCN2-IN-1 1mg
A20412-25GCN2-IN-1 25mg
A20412-50GCN2-IN-1 50mg
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