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FMP-API-1

CAT: 0804-HY-W288951-02Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-W288951-02Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FMP-API-1 is an A-kinase anchoring protein (AKAP) -PKA interaction inhibitor. FMP-API-1 binds to the allosteric site of PKA R subunits and increases the activity of PKA and AQP2 in PKA-knockout cell lines of renal cortical collecting ducts (mpkCCD cells) . FMP-API-1 has the potential for the study of nephrogenic diabetes insipidus (NDI) [1][2].
CAS Number
16523-28-7
UNSPSC
12352005
Hazard Statement
H317-H319
Target
PKA
Related Pathways
Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Metabolic Disease
Smiles
C1=CC(=C(C=C1CC2=CC(=C(C=C2)O)N)N)O
Molecular Formula
C13H14N2O2
Molecular Weight
230.26
Precautions
P261-P264-P272-P280-P302+P352-P362+P364-P501
References & Citations
[1]Ando F. Activation of AQP2 water channels by protein kinase A: therapeutic strategies for congenital nephrogenic diabetes insipidus. Clin Exp Nephrol. 2021 Oct;25 (10) :1051-1056.|[2]Fumiaki Ando, et al. AKAPs-PKA disruptors increase AQP2 activity independently of vasopressin in a model of nephrogenic diabetes insipidus. Nat Commun. 2018 Apr 12;9 (1) :1411.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

2-Amino-4-((3-amino-4-hydroxyphenyl)methyl)phenol
CAS Number16523-28-7
PubChem CID138746
IUPAC Name2-amino-4-[(3-amino-4-hydroxyphenyl)methyl]phenol
Molecular FormulaC13H14N2O2
Molecular Weight230.26
XLogP1.8
Topological Polar Surface Area92.5
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count17
Formal Charge0
Complexity226
SMILES
C1=CC(=C(C=C1CC2=CC(=C(C=C2)O)N)N)O
InChI
InChI=1S/C13H14N2O2/c14-10-6-8(1-3-12(10)16)5-9-2-4-13(17)11(15)7-9/h1-4,6-7,16-17H,5,14-15H2
InChIKey
KCFVSHSJPIVGCG-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-Amino-4-((3-amino-4-hydroxyphenyl)methyl)phenol
CAS: 16523-28-7
CID: 138746
Formula: C13H14N2O2
MW: 230.26
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight230.26
XLogP31.8
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass230.105527694
Monoisotopic Mass230.105527694
Topological Polar Surface Area92.5 Ų
Heavy Atom Count17
Formal Charge0
Complexity226
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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