FMP

• Description :

  FMP is a Platinum (IV) complexe. FMP significantly upregulates the expression of γ-H2AX and p53. FMP increases the production of ROS. FMP markedly upregulates the expressions of Apoptosis-related proteins (DR5, Fas, caspase-8, Cyt-c, caspase-3, cleaved-PARP1, Bax) . FMP shows antiproliferative activity against breast cancer[1].

• UNSPSC :

  12352211

• Target :

  Apoptosis; Bcl-2 Family; Caspase; MDM-2/p53; PARP; Reactive Oxygen Species (ROS)

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Field of Research :

  Cancer

• Smiles :

  COC1=CC=C(C2=COC3=CC(OCC(O[Pt](N)(O)(Cl)(Cl)N)=O)=CC=C3C2=O)C=C1

• Molecular Formula :

  C18H18Cl2N2O7Pt

• Molecular Weight :

  640.33

• References & Citations :

  [1]Cai L, et al. Platinum (IV) Complexes Trigger Death Receptors and Natural Killer Cells to Suppress Breast Cancer. J Med Chem. 2025 Jan 31.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Bax; Caspase 3; Caspase 8