ZIF-8

• Description:

  ZIF-8 (2-Methylimidazole zinc salt) is an anticancer agent that intrinsically induces pyroptosis through a caspase-1/gasdermin D (GSDMD) -dependent pathway[1].

• Product Name Alternative:

  2-Methylimidazole zinc salt

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H314

• Target:

  Caspase; Pyroptosis

• Related Pathways:

  Apoptosis; Immunology/Inflammation

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Smiles:

  CC1=NC=CN1[Zn]N2C=CN=C2C

• Molecular Formula:

  C8H10N4Zn

• Molecular Weight:

  227.59

• Precautions:

  H302, H314

• References & Citations:

  [1]Ding B, et al. ZIF-8 Nanoparticles Evoke Pyroptosis for High-Efficiency Cancer Immunotherapy. Angew Chem Int Ed Engl. 2023 Mar 1;62 (10) :e202215307.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  RT, stored under nitrogen

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [59061-53-9]