Tn antigen

• Description:

  Tn Antigen (Tn Epitope) (Compound 1) is a Trypanosoma cruzi trans-sialidase (TcTS) inhibitor with inhibition rate of 57% at 1 mM. Tn Antigen shows anti-trypanosomal activity with an IC50 of >0.5 mM. Tn Antigen can be used for the research of Chagas’ disease[1].

• Product Name Alternative:

  GalNAcα-O-Ser

• UNSPSC:

  12352005

• Hazard Statement:

  H302-H315-H319-H335

• Target:

  Parasite

• Related Pathways:

  Anti-infection

• Field of Research:

  Infection

• Smiles:

  O[C@@H]([C@H]1O)[C@@H](NC(C)=O)[C@@H](OC[C@H](N)C(O)=O)O[C@@H]1CO

• Molecular Formula:

  C11H20N2O8

• Molecular Weight:

  308.29

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations:

  [1]Martins-Teixeira MB, et al. α-Selective glycosylation affords mucin-related GalNAc amino acids and diketopiperazines active on Trypanosoma cruzi. Bioorg Med Chem. 2013 Apr 1;21 (7) :1978-87.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound2

• Clinical Information:

  No Development Reported

• CAS Number:

  [67262-86-6]